You are limited by the difference in gain between the high and low signals, the more gain the lower the saturation point, and there has to be a fair bit of overlap between the two signals to combine them properly. A balance has to be struck.
For a more technical breakdown on saturation point take a look at Jon Rista's post
https://www.cloudynights.com/topic/600061-a-little-confused-about-full-well-and-read-noise/
Also take a look at Dual ADC audio recording which operates in an analogous fashion.